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Aminergic and Peptidergic Receptors. Satellite Symposium of by E. S. Vizi PDF

By E. S. Vizi

ISBN-10: 0080263852

ISBN-13: 9780080263854

ISBN-10: 0080268390

ISBN-13: 9780080268392

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Additional info for Aminergic and Peptidergic Receptors. Satellite Symposium of the 3rd Congress of the Hungarian Pharmacological Society, Szeged, Hungary, 1979

Sample text

And also M c - N - A - 1 2 9 3 , s i g n i f i c a n t l y a l t e r e d the GYKI 11 121 adenylate c y c l a s e a c t i v i t y . T h e m u c o s a l enzyme a c t i v i t y d i m i n i s h e d by and 22 % a f t e r GYKI 11 1 2 1 - or M c - N - A - 1 2 9 3 - t r e a t m e n t s The h y p o t h a l a m i c these t r e a t m e n t s (Table 3 ) . adenylate cyclase activity depressed even a g r e a t e r extent; 32 a 40 and a 35 % i n h i b i t i o n w a s o b s e r v e d to after (Table 4 ) . CONCLUSIONS The f u n c t i o n a l and the b i o c h e m i c a l d a t a of t h e s e suggest that in v a r i e t y of t i s s u e s , i n h i b i t i o n of s y n t h e s i s c a u s e s an a l t e r a t i o n in the r e c e p t o r studies histamine sensitivity.

Lad et a l . 1 9 7 7 , S. S w i l l e n s et a l . 1 9 7 7 , R. W e s s e l s et a l . 1 9 7 9 9 but n e i t h e r of them c a n give p r e f e r e n c e at the m o m e n t . 37 SUMMARY Induction of b e t a - r e c e p t o r b i n d i n g sites w i t h the antagonist alprenolol was demonstrated using rabbit membranes preincubated with alprenolol 10 ^M and w a s h e d times with buffer. A concomitant decrease in t h e heart four basal a c t i v i t y of a d e n y l a t e c y c l a s e could be also d e m o n s t r a t e d i n c r e a s e in the i s o p r o t e r e n o l activation.

Arch. detergent- Biochem. B i o p h y s . 1 8 9 , 63 Lad, M . P . , W e l t o n , A . F . and R o d b e l l , M. distinct (1977) E v i d e n c e for g u a n i n e n u c l e o t i d e s i t e s in t h e r e g u l a t i o n of the g l u c a g o n r e c e p t o r and of a d e n y l a t e c y c l a s e a c t i v i t y . J. Chem. Biol. J. and L e v e y , G . S . (1972) Norepinephrine: d i s s o c i a t i o n of 3-receptor b i n d i n g from a d e n y l a t e activation in s o l u b i l i z e d m y o c a r d i u m .

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Aminergic and Peptidergic Receptors. Satellite Symposium of the 3rd Congress of the Hungarian Pharmacological Society, Szeged, Hungary, 1979 by E. S. Vizi


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