By Karsten Schrör
Written via a number one professional on Aspirin-related learn, this can be the 1st accomplished treaty of the heritage, pharmacological results and scientific purposes of 1 of the main profitable medications ever.The textual content is written with a large viewers in brain and to be with no trouble comprehensible for clinicians in addition to biomedical researchers and pharmacologists alike. The content material is modern and comprises the newest result of medical and educational study, with a balanced view at the disputed homes of this well-known drug.
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1947) Die Salizyls€aure. Arzneimittel forschungen 3, Verlag Dr. Werner Saenger, Berlin. 8 Schreiner, C. (1997) 100 Years Aspirin. The Future has Just Begun, Bayer AG. 9 Ebstein, W. and M€ uller, J. (1875) Weitere Mittheilungen € ber die Behandlung des Diabetes mellitus mit u € ber die Anwendung Carbols€aure nebst Bemerkungen u von Salicyls€aure bei dieser Krankheit. Berliner Klinische Wochenschrift, 12, 53–56. 10 Stricker, S. (1876) Über die Resultate der Behandlung der Polyarthritis rheumatica mit Salicyls€aure.
Molony, B. et al. (1994) In vitro dissolution versus in vivo evaluation of four different aspirin products. Drug Development and Industrial Pharmacy, 20, 1711–1723. 76 Blume, H. and Siewert, M. (1986) Zur Qualit€atsbeurteilung von acetylsalizyls€aurehaltigen Fertigarzneimitteln. 1. Mitteilung: Vergleichende Reihenuntersuchung zur pharmazeutischen Qualit€at handels€ ublicher ASS-Monopr€aparate. Pharmazeutische Zeitung, 47, 2953–2958. 77 Siewert, M. and Blume, H. (1988) Zur Qualit€atsbeurteilung von acetylsalizyls€aurehaltigen Fertigarzneimitteln.
HPLC separation and subsequent identiﬁcation of the spots by appropriate standards is the most frequentlyusedtechnology. Advantages are the simplicity and reproducibility of the method, a high sensitivity (detection limit about 100 ng/ ml), and the possibility of simultaneous deter- nous ﬂuorescence spectrometry (SDSFS) . This method appears to be the ﬁrst nonchromatographic technology for the simultaneous determination of aspirin and its major metabolites in one singleserum sample. The technique is not sensitive to several other drugs, found frequently in the sera of healthy subjects (antipyrine, ibuprofen, indomethacin, theophylline, and others).
Acetylsalicylic Acid by Karsten Schrör